By Armen A. Galoyan

Proline-rich polypeptides - specifically (PRP-1) galarmin and its structural analogues – are, while remoted from the neurosecretory granules of neurohypophysis of people and animals, a brand new kind of hypothalamic peptides. They paintings opposed to cardio, anaerobic, gram-positive, and gram-negative microorganisms in vivo, and don't have etiotropic houses. they're special and able substitutes to antibiotics, and, additionally, should be powerful opposed to traces, resembling MRSA, that strengthen resistance to antibiotics. Galarmin, an element of the mind neuroendocrine procedure produced by way of the neurosecretory cells of hypothalamus, possesses  immunomodulative, neuroprotective, antioxidant, antitumorigenic and hematopoietic houses. in addition, galarmin and its structural analogues are strong anti inflammatory  compounds. 

In addition to featuring an entire evaluation of the neuroimmune method, it emphasizes the antibacterial, neuroprotective, and neuroregenerative houses of proline-rich polypeptides.  It investigates the mechanism of galarmin’s motion in the course of various infectious tactics, the place it goals such risky pathogens as  Bacillus anthracis, Clostridium perfringens, Mycobacterium tuberculosis, and Methycillin resistant Staphylococcus aureus.   This study is critical from either a theoretical and a medical perspective, developing new customers for the fashionable pharmaceutical and neuroendocrine, neuroimmunological sciences.

Dr. Galoyan is a pioneer of the really good box of neuroimmunology. in the course of his 45-year lengthy profession, he has found a neuroendocrine immune method of the mind and pointed out a brand new kind of mind cytokines: proline-rich polypeptides. crucial of those, PRP-1 (galarmin) has been proven to own antibacterial homes and safeguard from yes neurotoxins.

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Brain Immune System Signal Molecules in Protection from Aerobic and Anaerobic Infections: 6 (Advances in Neurobiology) by Armen A. Galoyan


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